Study of Garlic Bulb Compound (Allium sativum L.) on Active Interaction as Analgetic-Anti-Inflammatory in Silico Kajian Dari Senyawa Umbi Bawang Putih (Allium sativum L.) terhadap Interaksi Aktif sebagai Analgetik-Antiinflamasi Secara in Silico

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Published: Nov 27, 2023
DOI: https://doi.org/10.36060/jfs.v9i2.96
Keywords:
1EQG, Analgetic-Anti-inflammatory, Ibuprofen, In Silico, Garlic Bulb

Main Article Content

Hesti Monikasari
Program Studi Farmasi – Fakultas Ilmu Kesehatan - Universitas Perjuangan Tasikmalaya
Richa Mardianingrum
Program Studi Farmasi – Fakultas Ilmu Kesehatan - Universitas Perjuangan Tasikmalaya
Kamiel Roesman Bachtiar
Program Studi Farmasi – Fakultas Ilmu Kesehatan - Universitas Perjuangan Tasikmalaya

Abstract

Pain is a form of emotional sensory discomfort associated with risk or damage to body tissues, this can arise when tissues are being damaged. The classification of pain is generally divided into two, namely acute pain and chronic pain. The treatment often used for acute pain (analgetic-anti-inflammatory) is ibuprofen. However, ibuprofen if consumed in the long term can cause some side effects for the body. The purpose of this study was to find candidates for medicinal ingredients from 96 compounds found in garlic bulbs (Allium sativum L.) as analgetic-anti-inflammatory. This research method uses experimental methods in silico which include molecular docking and molecular dynamics. The results of this study show that UBP20 compounds (tetracycline) have better toxicity than ibuprofen, as well as produce interactions that can be stabilized by the amino acids ARG120 and TYR355. Based on molecular dynamic results, UBP20 compounds have RMSD values of ±2.32 Å and ∆GTOTAL values of -24.27 kcal / mol. While Ibuprofen has an RMSD value of ±2.46 Å and ∆GTOTAL -35.21 kcal / mol. So it can be concluded that UBPP20 compounds have stable interactions with 1EQG receptors that can be used as candidates for analgetic-anti-inflammatory drugs, but do not yet have a lower ∆GTOTAL value than Ibuprofen (comparison drug).

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How to Cite
Monikasari, H., Mardianingrum, R., & Bachtiar, K. R. (2023). Study of Garlic Bulb Compound (Allium sativum L.) on Active Interaction as Analgetic-Anti-Inflammatory in Silico. Jurnal Farmasi Sandi Karsa, 9(2), 60-73. https://doi.org/10.36060/jfs.v9i2.96
Issue
Vol 9 No 2 (2023): Jurnal Farmasi Sandi Karsa (JFS)
Section
Articles
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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author Biographies

Hesti Monikasari, Program Studi Farmasi – Fakultas Ilmu Kesehatan - Universitas Perjuangan Tasikmalaya

Penulis 1

Richa Mardianingrum, Program Studi Farmasi – Fakultas Ilmu Kesehatan - Universitas Perjuangan Tasikmalaya

Penulis 2, Corresponding Author

Kamiel Roesman Bachtiar, Program Studi Farmasi – Fakultas Ilmu Kesehatan - Universitas Perjuangan Tasikmalaya

Penulis 3

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