Jurnal Farmasi Sandi Karsa

Study of Garlic Bulb Compound (Allium sativum L.) on Active Interaction as Analgetic-Anti-Inflammatory in Silico

Hesti Monikasari — 2023-11-27

Pain is a form of emotional sensory discomfort associated with risk or damage to body tissues, this can arise when tissues are being damaged. The classification of pain is generally divided into two, namely acute pain and chronic pain. The treatment often used for acute pain (analgetic-anti-inflammatory) is ibuprofen. However, ibuprofen if consumed in the long term can cause some side effects for the body. The purpose of this study was to find candidates for medicinal ingredients from 96 compounds found in garlic bulbs (Allium sativum L.) as analgetic-anti-inflammatory. This research method uses experimental methods in silico which include molecular docking and molecular dynamics. The results of this study show that UBP20 compounds (tetracycline) have better toxicity than ibuprofen, as well as produce interactions that can be stabilized by the amino acids ARG120 and TYR355. Based on molecular dynamic results, UBP20 compounds have RMSD values of ±2.32 Å and ∆G_TOTAL values of -24.27 kcal / mol. While Ibuprofen has an RMSD value of ±2.46 Å and ∆G_TOTAL -35.21 kcal / mol. So it can be concluded that UBPP20 compounds have stable interactions with 1EQG receptors that can be used as candidates for analgetic-anti-inflammatory drugs, but do not yet have a lower ∆G_TOTAL value than Ibuprofen (comparison drug).

The Potential of Hyperglycemia Combination of Watermelon (Citrullus lanatus) Rind Extract and Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract

Sainal Edi Kamal — 2023-11-27

This study aims to determine the potential hyperglycemia of the combination of Watermelon Skin Extract (Citrullus lanatus) and Red Dragon Fruit Skin Extract (Hylocereus polyrhizus). The research method used is the alloxane induction method. Rats were divided into 5 groups, namely positive control given metformin 45 mg / Kg BB, negative control given Na. CMC 1% w/v, and variations of test groups given combination extracts with concentration variations of 6% and 13.4%; 9% and 16.4%; and 12% and 19.4% then each group was induced alloxane at a dose of 24 mg / 200g BB. The results of the study on the negative control given NaCMC 1% did not show a decrease in blood sugar levels, in the positive control given metformin 45 mg / KgBB showed an average percent decrease of 94.12%, in the combination extract test group with a dose of 6% and 13.4% showed an average percent decrease of 25.04%; 9% and 16.4% % showed an average percent decrease of 24.69%; and 12% and 19.4% % showed an average percent decrease of 55.61%. Based on the results of this study, a combination extract of 12% and 19.4% can reduce blood sugar levels of white rats. This study proved that red watermelon peel extract and red dragon fruit peel extract have antihyperglycemia effects.

Study of the Profile of Use of Natural Ingredients and Preparations Increasing Body Immunity in Students Sandi Karsa Polytechnic

Sulfiyana H. Ambo Lau — 2023-11-27

Body immunity is an immune system designed to detect or destroy foreign objects that enter the body to avoid disease. Immunity is important to maintain so that the body remains healthy, one way is by consuming natural ingredients or preparations to increase body immunity. The purpose of this study was to determine the profile study of the use of natural materials and immune-enhancing preparations in Politeknik Sandi Karsa students. This type of research uses a descriptive method, namely research that includes surveys with data collection in the form of questionnaires with a total of 69 respondents. The sampling method uses Non Probability Sampling with Purposive Sampling techniques using questionnaires using the Opened Questionare questionnaire format in data collection and report recording. The results of this study show that there are still students who use natural ingredients in the form of ginger, lemongrass, honey, ginger, moringa leaves, turmeric and life connection leaves while the body's immunity-enhancing preparations are used such as vitamin C, immunos, stimuno, imboost force, vit Bcom-Z and Bcom and reject wind. So it can be concluded that the Profile Study of the Use of Natural Ingredients and Immune Enhancing Preparations in Sandi Karsa Polytechnic Students who use natural ingredients in the form of ginger is 20 respondents (29.00%) and immune boosting preparations using vitamin C are 19 respondents (27.55%).

Place to Buy Medicines for Community Self-medication in Bumi Findaria Mas 1 Moncongloe Housing, Maros Regency

Rina Asrina — 2023-11-27

Swamedikasi adalah upaya yang paling banyak dilakukan masyarakat untuk mengatasi penyakit sebelum
mencari pertolongan kepada tenaga kesehatan. Masyarakat biasanya berswamedikasi untuk penyakit-penyakit ringan yang dialami. Berbagai macam tempat pembelian obat yang biasanya digunakian oleh masyarakat yaitu apotek, warung kelontong, minimarket dan toko obat. Tujuan penelitian ini adalah untuk mengetahui mengenai tempat pembelian obat untuk swamedikasi masyarakat di Perumahan Bumi Findaria Mas 1 Moncongloe Kabupaten Maros. Metode yang digunakan dalam penelitian ini adalah metode deskriptif yaitu penelitian yang mencakup tentang survei dengan teknik pengumpulan data berupa kuisioner. Penelitian ini dilakukan di Perumahan Bumi Findaria Mas 1 Moncongloe Kabupaten Maros yang dilakukan pada Bulan September-Oktober Tahun 2023 dengan membagikan kuesioner pada 50 orang responden. Hasil penelitian menunjukkan bahwa responden lebih banyak membeli obat di minimarket yaitu 21 orang (42%), kemudian di apotek sebanyak 20 orang (40%), kemudian di warung sebanyak 9 orang (18%), dan tidak ada yang membeli di toko obat. Dari hasil tersebut disimpulkan bahwa sebagian masyarakat masih belum menyadari akan pentingnya informasi atau pengetahuan tentang obat sebelum obat tersebut dikonsumsi.

The Overview of Community Knowledge on the Use of Doen Antacid Drugs at Narisa Pharmacy

Herman Herman — 2023-11-27

Heartburn is a condition characterized by pain in the stomach area. Heartburn is caused by a high concentration of stomach acid. Disease with the same symptoms is gastritis but with different levels, inflammation of the gastric mucosa accompanied by damage or erosion of the mucosa. Gastritis can also occur due to infection from the bacterium Helicobacter pylori. The condition of antacid drugs does which is an over-the-counter drug that can be found anywhere is a drug that can relieve the disease, but in the service of purchasing this drug it takes people who struggle in the world of pharmacy such as pharmacists to provide information. Previous researchers have found that if you do not receive treatment that is not in accordance with medical indications it can be bad for patients, namely worsening disease conditions, decreased life expectancy, and increased health care costs. This is dangerous for buyers of these drugs if they are not right on target of the diseases and drugs they buy, so researchers are interested in seeing a picture of public knowledge about the use of Antacid Doen drugs at Narisa Pharmacy. The method used in this study is descriptive with survey techniques where data collection uses questionnaires as a measuring tool containing questions about several knowledge domains, namely Know (Know) Understand (Comprehension) Analyze (Analysis) Apply (Application) Synthesize Unite Elements into a whole then use the Gutman scale as a choice of Yes and No answers, of course prioritizing respondents' rights including inclusion and exclusion criteria. This study is a Non Probability Sampling study with an Accidental Sampling approach, namely anyone who by chance comes to buy Antacid drugs Doen met at the pharmacy, the population in this study is the surrounding community who came to buy drugs at Apotek Narisa with the number of samples based on the selection of results from the Slovin formula as many as 68 respondents. The results showed that based on the total percentage value of p score = 85.61% entered the category (76%-100%) which is can be conluded as a category of good knowledge.

Level of Public Knowledge of Over-the-Counter Self-Medication And free medicines are limited to Jalan Bung Rt 003 Rw 001 Tamalanrea Jaya Village, Makassar City

Murniati Murniati — 2023-11-27

Self-medication is the use of non-prescription medications by an individual on their own initiative. Self-medication with over-the-counter medicines and limited over-the-counter medicines can be risky if done continuously to treat diseases that do not go away. Self-medication requires knowledge before doing it so that there is no mistake in using the medicine, so this research aims to determine the level of public knowledge regarding the use of over-the-counter medicines and over-the-counter medicines for self-medication. held in April-May 2023 on Jl. Bung Rt 003 Rw 001 Tamalanrea Jaya Village, Tamalanrea District, Makassar City. This type of research uses a descriptive method, namely research that includes surveys with data collection in the form of questionnaires with a total of 79 respondents. The sampling technique uses a non-probability sampling technique, namely purposive sampling. The results of this research show that the percentage of respondents' answers is 91.45%. Based on these results, it can be concluded that the level of public knowledge regarding self-medication with over-the-counter drugs and over-the-counter drugs is included in the high category.

Level of Compliance of TB Patients to the Use of TB Drugs at Puskesmas Tamalanrea Jaya Makassar City

Zulfiah Zulfiah — 2023-11-27

TB atau Tuberkulosis adalah suatu penyakit tinfeksi yang disebabkan oleh bakteri Mycobacterium tuberculosis yang dapat menular melalui percikan dahak. Tuberkulosis ini dapat disebabkan oleh bakteri Mycobacterium tuberculosis. Penelitian ini bertujuan untuk mengetahui tingkat kepatuhan pasien TBC terhadap penggunaan obat TBC di puskesmas Tamalanrea Jaya kota Makassar. Metode yang digunakan dalam penelitian ini adalah deskriptif yaitu penelitian yang mencakup tentang survei dengan teknik pengumpulan data berupa kuesioner. Penelitian ini dilakukan di Puskesmas Tamalanrea Jaya Kota Makassar di jalan perintis kemerdekaan IV Kecamatan Tamalanrea Kelurahan Tamalanrea Jaya Kota Makassar penelitian ini dilakukan pada bulan April-Agustus 2021 terdapat 10 pasien TBC. Hasil penelitian menunjukkan bahwa pasien TBC memiliki kepatuhan yang tinggi 80%. Semua pasien mempunyai motivasi dan pengetahuan yang tinggi serta dukungan dari petugas pelayanan kesehatan di puskesmas (semua petugas senantiasa memberikan informasi tentang TB, sangat mendukung dan peduli kepada pasien dan mempunyai cukup waktu untuk konsultasi).

Overview of The Medicine Storage System In Puskesmas "A" Makassar City

Megawati Megawati — 2023-11-27

The drug storage system is a drug storage management activity carried out at Puskesmas "A" Makassar City. This study aims to determine the suitability of the drug storage system at Puskesmas "A" Makassar City based on the Regulation of the Minister of Health of the Republic of Indonesia No. 74 of 2016 concerning Pharmaceutical Service Standards at Puskesmas. The type of research used is observational research by observing research objects and variables and then the results are presented in a questionnaire/interview sheet in the form of a table. Based on the results of this research, it can be concluded that the drug storage system at Puskesmas "A" Makassar City has met the standards of Regulation of the Minister of Health of the Republic of Indonesia No. 74 of 2016 concerning Pharmaceutical Service Standards at Puskesmas, especially aspects of drug storage management. Although there are still several aspects that have not been fulfilled.

Study of Most Number of Medication Use in Two Diseases Biggest in Tamalanrea Jaya Health Center in Makassar city

Muhammad Farid Hasyim — 2023-11-27

Medicines play an important role in health services. In terms of drug use, the most important step to consider is correct diagnosis, resulting in a rational, effective, safe and economical prescription. This research is a descriptive study aimed at finding out the level of drug use for the two biggest diseases, namely ARI and gastritis. Data collection was carried out by looking at prescriptions from people with acute respiratory infections and gastritis who entered the Tamalanrea Jaya Health Center from January to March 2023. The results of this research showed that from January to March the use of medicines decreased slightly due to the influence of good weather. . From January to March, the total number of patients indicated for ISPA was 204, with the highest use of the drug dexamethasone being 1,770, while the number of patients indicated for gastritis was 180 with the highest use of the drug ranitidine being 1,460.

The Level of Public Knowledge About Headache Medicine Advertisements for the Use of Self-medication in the Community Ance Dg Ngoyo V, Panakukang District, Makassar City

Yuniharce Kadang — 2023-11-27

Medicines play an important role in health services. In terms of drug use, the most important step to consider is correct diagnosis, resulting in a rational, effective, safe and economical prescription. This research is a descriptive study aimed at finding out the level of drug use for the two biggest diseases, namely ARI and gastritis. Data collection was carried out by looking at prescriptions from people with acute respiratory infections and gastritis who entered the Tamalanrea Jaya Health Center from January to March 2023. The results of this research showed that from January to March the use of medicines decreased slightly due to the influence of good weather. From January to March, the total number of patients indicated for ISPA was 204, with the highest use of the drug dexamethasone being 1,770, while the number of patients indicated for gastritis was 180 with the highest use of the drug ranitidine being 1,460.

Description of Public Knowledge About DAGUSIBU Antibiotic Drugs in RW 001 Tamalanrea Jaya Village Makassar City in 2023

Nurul Izza AR. — 2023-11-27

Antibiotics are therapy to treat bacterial infections. Antibiotics must be used rationally to optimize their function. According to a study from the National Academy of Sciences (NAS) of the United States, antibiotic use increased 65.0% from 2000 to 2015. One way to properly and correctly manage antibiotic drugs is through DAGUSIBU socialization. A preliminary survey was conducted on 5 residents, 1 person had good knowledge and 4 people had poor knowledge regarding the use and disposal of antibiotics. The aim of this research is to determine the level of public knowledge about the antibiotic drug DAGUSIBU in RW 001, Tamalanrea Jaya Village, Makassar City in 2021. This research uses a quantitative descriptive survey method. The sampling technique used is non-probability sampling. Data collection was carried out based on primary data in the form of a questionnaire, with a total of 50 respondents. The results of the study showed that knowledge about how to obtain antibiotic drugs was 58.0% in the quite good category, knowledge about how to use antibiotic drugs was 66.0% in the quite good category, knowledge about how to store antibiotic drugs was 84.6% in the good category. and knowledge about how to dispose of antibiotic drugs was 76.0% in the quite good category.