Antipyretic Effectiveness Test from Dragon (Pyrosia piloselloides) (L) M. G. Price) Leaves Extract in Male Marmutes (Cavia Procellus)
Article Sidebar
Main Article Content
Abstract
This study aims to determine Effectiveness Of Dragon Scale Leaves (Pyrrosia piloselloides (L.) M. G. Price) As An Antipyretic In Male Marmut (Cavia porcellus) induced with 5% peptone. This study used 15 male guinea pigs which were divided into V groups. roup I was given negative control (Na. CMC 1% w/v), groups II, III and IV were given dragon scales leaf extract at a dose of 250 mg/kg, 500 mg/kg, and 750 mg/kg and group V was given a positive control. (Paracetamol). previously induced with 5% peptone subcutan. measurements of body temperature rectally were carried out every 30 minutes, survived 4 hours. The results showed that the administration of dragon scales leaf extract at a dose of 250 mg/kg, 500 mg/kg, and 750 mg/kg of body weight gave an antipyretic effect against male guinea pigs and the most optimal effect is obtained at a dose of 750 mg/kgBW which is 129,05% compared to paracetamol which is 146,19%.
Article Details
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
References
Rinidar, M. Isa, T. Armansyah, 2020. Pengantar Farmakologi Analgesik-Antipiretik-Anti Inflamasi. Syiah Kuala University Press.
Rombetasik, M.P., Nayoan, C.R., Danu, S.S., 2017. Efek Antipiretika Jus Buah Mentimun (Cucumis Sativus L.) (Studi quasi eksperimental pre-post design pada mencit yang diinduksi demam dengan penyuntikan vaksin DPT). Medica Hospitalia: Journal of Clinical Medicine 4. https://doi.org/10.36408/mhjcm.v4i3.334
Sagita, D., Ichwani, M.N., Linuria, L., 2017. Skrining aktifitas antibakteri dari ekstrak Sisik Naga (Pyyrosia piloselloides (L) M. G. Price). Riset Informasi Kesehatan 6, 115–119. https://doi.org/10.30644/rik.v6i2.101
Walter, E.J., Hanna-Jumma, S., Carraretto, M., Forni, L., 2016. The pathophysiological basis and consequences of fever. Crit Care 20. https://doi.org/10.1186/s13054-016-1375-5
Widyasari, R., Yuspitasari, D., Fadli, F., Masykuroh, A., Tahuhiddah, W., 2018. Uji Aktivitas Antipiretik Ekstrak Daun Sisik Naga (Pyrrosia piloselloides (L.) M. G. Price) Terhadap Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Yang Diinduksi Pepton 5%. Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK) 15, 22–28.
Yuan, Daud., 2020. Studi Literatur: Efek Farmakologi Daun Sisik Naga (Drymoglossum piloselloides). (Diploma) Universitas_Muhammadiyah_Mataram.